Trends in Bacterial Resistance to Fluoroquinolones

Hidden Selection of Bacterial Resistance to Fluoroquinolones In Vivo: The Case of Legionella pneumophila and Humans

BACKGROUND Infectious diseases are the leading cause of human morbidity and mortality worldwide. One dramatic issue is the emergence of microbial resistance to antibiotics which is a major public health concern. Surprisingly however, such in vivo adaptive ability has not been reported yet for many intracellular human bacterial pathogens such as Legionella pneumophila. METHODS We examined 82 u...

Does mutation rate drive resistance to fluoroquinolones?

Molecular determinants of the bacterial resistance to fluoroquinolones: a computational study.

Quinolones constitute a large class of antibacterial agents whose action is mediated through the formation of a ternary complex with DNA and either, DNA Gyrase or topoisomerase IV, resulting in the inhibition of DNA replication. In order to get a deeper insight into the features of the complex formation, we carried out docking studies of fifteen diverse quinolones to the cleaved topoisomerase I...

Fluoroquinolones compared to 1% azithromycin in DuraSite® for bacterial conjunctivitis

In a recent issue of Clinical Ophthalmology, Friedlaender and Protzko (2007) review the development and effi cacy of 1% azithromycin in DuraSite ® (AzaSite™, Inspire Pharmaceuticals , Inc., Durham, NC) for the treatment of bacterial conjunctivitis. The authors conclude that 1% azithromycin in DuraSite offers a simplifi ed dosing regimen with sustained bactericidal levels that decrease resistanc...

Mechanisms of clinical resistance to fluoroquinolones in Staphylococcus aureus.

Mechanisms of Staphylococcus aureus resistance to fluoroquinolones were characterized. Subunit A and B proteins of DNA gyrase were partially purified from fluoroquinolone-susceptible strain SA113 and resistant isolate MS16405, which was 250- to 1,000-fold less susceptible to fluoroquinolones such as ciprofloxacin, norfloxacin, ofloxacin, temafloxacin, and sparfloxacin than SA113 was. The superc...